1) The Biltmore Estate, North Carolina
The Biltmore Estate is in North Carolina and is considered to be the largest home in the U.S. with a staggering 135,280 square feet! The home was originally built for the Vanderbilt family who earned their fortune through railroads. It has 43 bathrooms, 65 fireplaces and 35 bedrooms! It was originally opened in 1895 and become open to the public in 1930.